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BMF anticorps (C-Term)

BMF Reactivité: Humain WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499479
  • Antigène Voir toutes BMF Anticorps
    BMF (Bcl2 Modifying Factor (BMF))
    Épitope
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 39
    • 15
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 34
    • 4
    • 3
    Lapin
    Clonalité
    • 34
    • 7
    Polyclonal
    Conjugué
    • 24
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BMF est non-conjugé
    Application
    • 33
    • 19
    • 16
    • 8
    • 5
    • 4
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    Bmf antibody was raised with a synthetic peptide corresponding to 14 amino acids near the carboxy terminus of human Bmf.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    Human Bmf (C-Terminus) Peptide
    Isotype
    IgG
    Top Product
    Discover our top product BMF Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: Bmf antibody can be used for detection of Bmf at 2 μg/mL. HepG2 or 293 celllysate can be used as a positive control and a band at approximately 25 kDa can bedetected. Immunofluorescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    BMF (Bcl2 Modifying Factor (BMF))
    Autre désignation
    BMF (BMF Produits)
    Synonymes
    anticorps BMF, anticorps AW260063, anticorps AW411872, anticorps Bcl2 modifying factor, anticorps Bcl2 modifying factor L homeolog, anticorps BCL2 modifying factor, anticorps BMF, anticorps bmf.L, anticorps Bmf
    Sujet
    Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor) (1). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell\'s actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program (1,2). Bmf is constitutively expressed in many tissues (1,2).Synonyms: Bcl-2-modifying factor
    ID gène
    90427
    NCBI Accession
    NP_277038
    UniProt
    Q96LC9
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