DcR2 anticorps (Intracellular)

N° du produit ABIN499724

Détail du produit anti-DcR2 anticorps

Antigène: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Épitope: AA 249-263, Intracellular

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DcR2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: DcR2 antibody was raised against a peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.

Purification: Affinity Chromatography purified via peptide column

Immunogène: Human DcR2 (Intracellular Domain) Peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1/1000 to 1/2000. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Références pour anticorps anti-DcR2 (ABIN499724)

Liu, Hawkins, Vilgelm, Pawlikowski, Ecsedy, Sosman, Kelley, Richmond: "Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 21, Issue 23, pp. 5338-48, (2015) (PubMed).

Détails sur DcR2

Antigène: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Autre désignation: CD264 / TRAILR4 (TNFRSF10D Produits)

Synonymes: anticorps TNFRSF10D, anticorps CD264, anticorps DCR2, anticorps TRAIL-R4, anticorps TRAILR4, anticorps TRUNDD, anticorps TNF receptor superfamily member 10d, anticorps tumor necrosis factor receptor superfamily member 10D, anticorps TNFRSF10D, anticorps LOC716901

Sujet: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1-3). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (4-6). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.Synonyms: DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRAIL-R4, TRUNDD, Tumor necrosis factor receptor superfamily member 10D

ID gène: 8793

UniProt: Q9UBN6

Pathways: Apoptose