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FRMPD4 anticorps (Center)

FRMPD4 Reactivité: Humain WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499861
  • Antigène Voir toutes FRMPD4 Anticorps
    FRMPD4 (FERM and PDZ Domain Containing 4 (FRMPD4))
    Épitope
    • 1
    • 1
    Center
    Reactivité
    Humain
    Hôte
    • 1
    • 1
    Lapin
    Clonalité
    • 1
    • 1
    Polyclonal
    Conjugué
    • 2
    Cet anticorp FRMPD4 est non-conjugé
    Application
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    FRMPD4 antibody was raised against an 18 amino acid peptide from near the center of human FRMPD4.
    Isotype
    IgG
  • Indications d'application
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody (in aliquots) at -20 °C.
  • Antigène
    FRMPD4 (FERM and PDZ Domain Containing 4 (FRMPD4))
    Autre désignation
    FRMPD4 (FRMPD4 Produits)
    Synonymes
    anticorps RGD1566031, anticorps PDZD10, anticorps PDZK10, anticorps Gm196, anticorps PKAP1, anticorps Pdzd10, anticorps Pdzk10, anticorps Preso1, anticorps FERM and PDZ domain containing 4, anticorps Frmpd4, anticorps FRMPD4, anticorps frmpd4
    Sujet
    The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus. It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions. Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width, conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology. The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission.Synonyms: FERM and PDZ domain-containing protein 4, KIAA0316, PDZ domain-containing protein 10, PDZD10, PDZK10, PSD-95-interacting regulator of spine morphogenesis, Preso
    ID gène
    9758
    NCBI Accession
    NP_055543
    UniProt
    Q14CM0
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