anticorps C79673, anticorps Kindlin3, anticorps RGD1310168, anticorps MGC69069, anticorps MGC88900, anticorps KIND3, anticorps MIG-2, anticorps MIG2B, anticorps UNC112C, anticorps URP2, anticorps URP2SF, anticorps zgc:64101, anticorps fermitin family member 3, anticorps fermitin family member 3 L homeolog, anticorps fermitin family member 3b, anticorps Fermt3, anticorps fermt3.L, anticorps fermt3, anticorps FERMT3, anticorps fermt3b
Sujet
The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.Synonyms: Fermitin family homolog 3, KIND3, Kindlin-3, MIG2-like protein, MIG2B, URP2, Unc-112-related protein 2