TP53AIP1 anticorps (N-Term)

N° du produit ABIN500433

Détail du produit anti-TP53AIP1 anticorps

Antigène: TP53AIP1 (P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TP53AIP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody dreacts to p53AIP1. It will detect all three isoforms.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatograpy

Immunogène: p53AIP1 antibody was raised against a 15 amino acid peptide from near the amino terminus of human p53AIP1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 4 - 8 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-TP53AIP1 (ABIN500433)

Ohno, Naito, Mukai, Yabuta, Nojima: "ELAS1-mediated inhibition of the cyclin G1-B'γ interaction promotes cancer cell apoptosis via stabilization and activation of p53." dans: Oncogene, Vol. 34, Issue 49, pp. 5983-96, (2016) (PubMed).

Détails sur TP53AIP1

Antigène: TP53AIP1 (P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1))

Autre désignation: TP53AIP1 (TP53AIP1 Produits)

Synonymes: anticorps P53AIP1, anticorps tumor protein p53 regulated apoptosis inducing protein 1, anticorps TP53AIP1

Sujet: The p53 tumor-suppressor protein can induce apoptosis through transcriptional activation of several genes. One such protein p53AIP was initially identified through direct cloning of p53 binding sequences from human genomic DNA. Its expression is inducible by p53 following p53 phosphorylation on Ser-46, and ectopic expression of p53AIP leads to apoptotic cell death. Both the phosphorylation of p53 and the induction of p53AIP were blocked by inhibiting the expression of p53DINP1 by the introduction of antisense oligonucleotides to p53DINP1, suggesting that the apoptosis associated with p53AIP expression is regulated by p53DINP1. Finally, as adenovirus-mediated introduction of p53AIP has been shown to suppress tumor growth in vivo, it has been suggested that p53AIP gene transfer may become a useful strategy for the treatment of p53-resistant cancers. Three isoforms of p53AIP are known to existSynonyms: p53-regulated apoptosis-inducing protein 1, p53AIP1

ID gène: 63970

UniProt: Q9HCN2