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RNASEH2A anticorps (Center)

RNASEH2A Reactivité: Humain, Rat, Souris WB, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500622
  • Antigène Voir toutes RNASEH2A Anticorps
    RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))
    Épitope
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    • 21
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 19
    • 4
    Lapin
    Clonalité
    • 22
    • 1
    Polyclonal
    Conjugué
    • 20
    • 1
    • 1
    • 1
    Cet anticorp RNASEH2A est non-conjugé
    Application
    • 19
    • 10
    • 10
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Specificité
    This antibody detects RNAse H2A.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogène
    RNAse H2A antibody was raised against a 17 amino acid peptide near the center of human RNAse H2A.
    Isotype
    IgG
    Top Product
    Discover our top product RNASEH2A Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 1 - 2 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to 3 months, and at -20 °C thereafter.
  • Zimmermann, Murina, Reijns, Agathanggelou, Challis, Tarnauskaitė, Muir, Fluteau, Aregger, McEwan, Yuan, Clarke, Lambros, Paneesha, Moss, Chandrashekhar, Angers, Moffat, Brunton, Hart, de Bono et al.: "CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. ..." dans: Nature, Vol. 559, Issue 7713, pp. 285-289, (2019) (PubMed).

    Bartsch, Damme, Regen, Becker, Garrett, Hölter, Knittler, Borowski, Waisman, Glatzel, Fuchs, Gailus-Durner, Hrabe de Angelis, Rabe: "RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation." dans: Frontiers in immunology, Vol. 9, pp. 587, (2018) (PubMed).

    Cuadrado, Michailidou, van Bodegraven, Jansen, Sluijs, Geerts, Couraud, De Filippis, Vescovi, Kuijpers, Hol: "Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3623-33, (2015) (PubMed).

  • Antigène
    RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))
    Autre désignation
    RNASEH2A (RNASEH2A Produits)
    Synonymes
    anticorps 2400006P09Rik, anticorps RNASEHI, anticorps RNHIA, anticorps RNHL, anticorps zgc:56307, anticorps AGS4, anticorps JUNB, anticorps ribonuclease H2 subunit A, anticorps ribonuclease H2, large subunit, anticorps ribonuclease H2, subunit A, anticorps ribonuclease H2 subunit A L homeolog, anticorps rnaseh2a, anticorps RNASEH2A, anticorps Rnaseh2a, anticorps rnaseh2a.L
    Sujet
    Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits, all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.Synonyms: AGS4, Aicardi-Goutieres syndrome 4 protein, RNASEHI, RNAse H2A, RNHIA, RNase H2 subunit A, RNase HI large subunit, Ribonuclease H2 subunit A, Ribonuclease HI large subunit, Ribonuclease HI subunit A
    ID gène
    10535
    UniProt
    O75792
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