RNASEH2A anticorps (Center)
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- Antigène Voir toutes RNASEH2A Anticorps
- RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))
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Épitope
- Center
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Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RNASEH2A est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Specificité
- This antibody detects RNAse H2A.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, mouse, rat
- Purification
- Peptide affinity chromatography
- Immunogène
- RNAse H2A antibody was raised against a 17 amino acid peptide near the center of human RNAse H2A.
- Isotype
- IgG
- Top Product
- Discover our top product RNASEH2A Anticorps primaire
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- Indications d'application
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ELISA. Western blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2 - 8 °C for up to 3 months, and at -20 °C thereafter.
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CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. ..." dans: Nature, Vol. 559, Issue 7713, pp. 285-289, (2019) (PubMed).
: "RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation." dans: Frontiers in immunology, Vol. 9, pp. 587, (2018) (PubMed).
: "Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3623-33, (2015) (PubMed).
: "
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CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. ..." dans: Nature, Vol. 559, Issue 7713, pp. 285-289, (2019) (PubMed).
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- Antigène
- RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))
- Autre désignation
- RNASEH2A (RNASEH2A Produits)
- Synonymes
- anticorps 2400006P09Rik, anticorps RNASEHI, anticorps RNHIA, anticorps RNHL, anticorps zgc:56307, anticorps AGS4, anticorps JUNB, anticorps ribonuclease H2 subunit A, anticorps ribonuclease H2, large subunit, anticorps ribonuclease H2, subunit A, anticorps ribonuclease H2 subunit A L homeolog, anticorps rnaseh2a, anticorps RNASEH2A, anticorps Rnaseh2a, anticorps rnaseh2a.L
- Sujet
- Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits, all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.Synonyms: AGS4, Aicardi-Goutieres syndrome 4 protein, RNASEHI, RNAse H2A, RNHIA, RNase H2 subunit A, RNase HI large subunit, Ribonuclease H2 subunit A, Ribonuclease HI large subunit, Ribonuclease HI subunit A
- ID gène
- 10535
- UniProt
- O75792
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