Recognizes mouse and rat Slc7a8. Has been reported to work in human samples (Wirth,et al.; 2009), but was not tested in-house.Detects a -50kDa Slc7a8 band in wild type mouse brain, kidney, jejunum, ileum and othertissues, which is absent in knock-out animals. ln some tissues the antibody detects anadditional unknown 38kDa band.
Réactivité croisée (Details)
Other species not tested.Detects a ~50 kDa Slc7a8 band in wild type mouse brain, kidney, jejunum, ileum and other tissues, which is absent in knock-out animals. In some tissues the antibody detects an additional unknown 38 kDa band.
Purification
Antigen affinity purified.
Immunogène
Synthetic peptide corresponding to a partial sequence of mouse Slc7a8 (Q9QXW9).
anticorps LAT2, anticorps LPI-PC1, anticorps Lat2, anticorps Lat4, anticorps XAA2, anticorps lat2, anticorps lpi-pc1, anticorps 4F2LC-5, anticorps AA408822, anticorps si:ch211-14a17.3, anticorps si:zc14a17.3, anticorps slc7a8, anticorps solute carrier family 7 member 8, anticorps solute carrier family 7 member 8 L homeolog, anticorps solute carrier family 7 (amino acid transporter, L-type), member 8, anticorps solute carrier family 7 (cationic amino acid transporter, y+ system), member 8, anticorps solute carrier family 7 (amino acid transporter light chain, L system), member 8b, anticorps SLC7A8, anticorps Slc7a8, anticorps slc7a8.L, anticorps slc7a8, anticorps slc7a8b
Sujet
L-type amino acid transporter (LAT) family members are Na(+)-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 (SLC43A1) and LAT4 (SLC43A2) are responsible for the majority of cellular leucine uptake. They show increased expression in many cancers and are critical for control of protein translation and cell growth through the mTORC1 pathway. The increased transporter expression observed in cancers is regulated by transcriptional pathways such as hormone receptors, c-myc and nutrient starvation responses.