RASGRP2 anticorps

N° du produit ABIN5564283

Détail du produit anti-RASGRP2 anticorps

Antigène: RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASGRP2 est non-conjugé

Application: Western Blotting (WB)

Specificité: Recognizes human and mouse RasGRP2 phosphorylated at pSer587 (human isoform 1), pSer586 (mouse) or pSer649 (human isoform 2).

Réactivité croisée: Humain, Souris

Immunogène: Synthetic phosphopeptide corresponding to a partial sequence of human RasGRP2 containing the phosphorylated serine [pS] of the following sequence stretch (-SFSLPRPGRRG[pS]RPPE-IREEEVQTV-).

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 2 mg/mL BSA and 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: +4°C
Stable for at least 6 months after receipt when stored at +4°C.

Date de péremption: 6 months

Détails sur RASGRP2

Antigène: RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))

Autre désignation: RasGRP2 (RASGRP2 Produits)

Synonymes: anticorps CALDAG-GEFI, anticorps CDC25L, anticorps xrasgrp2, anticorps RASGRP2, anticorps Caldaggef1, anticorps CalDAG-GEFI, anticorps rasgrp2, anticorps RAS guanyl releasing protein 2, anticorps RAS guanyl releasing protein 2 (calcium and DAG-regulated) S homeolog, anticorps RAS, guanyl releasing protein 2, anticorps RAS guanyl releasing protein 2 (calcium and DAG-regulated) L homeolog, anticorps RASGRP2, anticorps rasgrp2.S, anticorps Rasgrp2, anticorps rasgrp2.L

Sujet: RasGRP2 functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating small GTPases, including Rap1/RAS3, through the exchange of bound GDP for GTP. It may also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. The protein is expressed in platelets, neutrophils and T lymphocytes. RasGRP2 functions in aggregation of platelets and adhesion of T lymphocytes and neutrophils probably through inside-out integrin activation. S587 was identified as the major PKA phosphorylation. Phosphorylation of S587 correlated with the inhibitory effect of PKA on Rap1b activation in platelets. In vitro, ERK1/2 phosphorylates RasGRP2 at Ser394 to limit its exchange activity and inhibits its ability to activate the small GTPase Rap1 that ultimately leads to decreased activation of ERK1/2 in cells.

UniProt: Q7LDG7

Pathways: TCR Signaling