GCLC anticorps (AA 528-637)

N° du produit ABIN561050

Détail du produit anti-GCLC anticorps

Antigène: GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))

Épitope: AA 528-637

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GCLC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Fonction: Mouse monoclonal antibody raised against a partial recombinant GCLC.

Séquence: EGVFPGLIPI LNSYLENMEV DVDTRCSILN YLKLIKKRAS GELMTVARWM REFIANHPDY KQDSVITDEM NYSLILKCNQ IANELCECPE LLGSAFRKVK YSGSKTDSSN

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: GCLC (NP_001489, 528 a.a. ~ 637 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 3H1

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: In 1x PBS, pH 7.4

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-GCLC (ABIN561050)

Sugiyama, Ebinuma, Nakamoto, Sakasegawa, Murakami, Chu, Usui, Ishibashi, Wakayama, Taniki, Murata, Saito, Fukasawa, Saito, Yamagishi, Wakita, Takaku, Hibi, Saito, Kanai: "Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus." dans: PLoS ONE, Vol. 9, Issue 4, pp. e94460, (2014) (PubMed).

Venè, Cardinali, Arena, Ferrari, Benelli, Minghelli, Poggi, Noonan, Albini, Tosetti: "Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress." dans: Neoplasia (New York, N.Y.), Vol. 16, Issue 9, pp. 710-22, (2014) (PubMed).

Li, Gunter, Fukagawa: "Differential activation of the inflammasome in THP-1 cells exposed to chrysotile asbestos and Libby "six-mix" amphiboles and subsequent activation of BEAS-2B cells." dans: Cytokine, Vol. 60, Issue 3, pp. 718-30, (2012) (PubMed).

Fan, Liu, Hao, Wang, Robinson, Monnier: "The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis." dans: PLoS ONE, Vol. 7, Issue 11, pp. e50832, (2012) (PubMed).

Abel, Bubel, Simper, Powell, McClellan, Andreeff, MacLeod, DiGiovanni: "Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway." dans: Toxicology and applied pharmacology, Vol. 255, Issue 2, pp. 176-83, (2011) (PubMed).

Hardwick, Fisher, Canet, Lake, Cherrington: "Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease." dans: Drug metabolism and disposition: the biological fate of chemicals, Vol. 38, Issue 12, pp. 2293-301, (2010) (PubMed).

Détails sur GCLC

Antigène: GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))

Autre désignation: GCLC (GCLC Produits)

Sujet: Full Gene Name: glutamate-cysteine ligase, catalytic subunit
Synonyms: GCS,GLCL,GLCLC

ID gène: 2729

NCBI Accession: NM_001498

Pathways: Cell RedoxHomeostasis