BCR anticorps (AA 139-280)

N° du produit ABIN5611130

Détail du produit anti-BCR anticorps

Antigène: BCR (Breakpoint Cluster Region (BCR))

Épitope: AA 139-280

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCR est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)

Purification: purified

Immunogène: Purified recombinant fragment of human BCR (AA: 139-280) expressed in E. coli.

Clone: 6B5E12

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: N/A, IHC: N/A

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Détails sur BCR

Antigène: BCR (Breakpoint Cluster Region (BCR))

Autre désignation: BCR (BCR Produits)

Synonymes: anticorps si:dkey-83d9.7, anticorps zK83D9.7, anticorps BCR, anticorps ALL, anticorps BCR1, anticorps CML, anticorps D22S11, anticorps D22S662, anticorps PHL, anticorps 5133400C09Rik, anticorps AI561783, anticorps AI853148, anticorps mKIAA3017, anticorps breakpoint cluster region, anticorps BCR, RhoGEF and GTPase activating protein, anticorps bcr, anticorps BCR, anticorps Bcr

Sujet:

Description: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Aliases: ALL, CML, PHL, BCR1, D22S11, D22S662

Poids moléculaire: 142.8 kDa

ID gène: 613

HGNC: 613

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling