SQSTM1 anticorps (Sequestosome 1) (AA 1-440)

Details for Product anti-SQSTM1 Antibody No. ABIN563860, Fournisseur: Connectez-vous pour afficher
Antigène
  • SQSTM1
  • sqstm1
  • MGC79491
  • A170
  • OSIL
  • PDB3
  • ZIP3
  • p60
  • p62
  • p62B
  • OSF-6
  • Osi
  • STAP
  • ZIP
  • sb:cb621
  • zgc:85784
  • sequestosome 1
  • sequestosome 1 L homeolog
  • SQSTM1
  • sqstm1
  • Sqstm1
  • sqstm1.L
Épitope
AA 1-440, full length
68
42
36
36
25
20
19
16
15
14
12
12
11
9
9
8
7
6
5
4
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
372
191
136
8
5
5
5
4
4
4
2
2
2
2
2
1
1
1
1
Hôte
Souris
313
50
6
3
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp SQSTM1 est non-conjugé
19
17
16
12
12
12
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), ELISA, Western Blotting (WB)
309
120
102
95
72
70
38
36
28
22
18
13
4
3
2
Options
Fournisseur
Connectez-vous pour afficher
N° du produit (Fournisseur)
Connectez-vous pour afficher
Immunogène SQSTM1 (AAH03139.1, 1 a.a. ~ 440 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen sequence: MASLTVKAYL LGKEDAAREI RRFSFCCSPE PEAEAEAAAG PGPCERLLSR VAALFPALRP GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRRDHR PPCAQEAPRN MVHPNVICDG CNGPVVGTRY KCSVCPDYDL CSVCEGKGLH RGHTKLAFPS PFGHLSEGFS HSRWLRKVKH GHFGWPGWEM GPPGNWSPRP PRAGEARPGP TAESASGPSE DPSVNFLKNV GESVAAALSP LGIEVDIDVE HGGKRSRLTP VSPESSSTEE KSSSQPSSCC SDPSKPGGNV EGATQSLAEQ MRKIALESEG RPEEQMESDN CSGGDDDWTH LSSKEVDPST GELQSLQMPE SEGPSSLDPS QEGPTGLKEA ALYPHLPPEA DPRLIESLSQ MLSMGFSDEG GWLTRLLQTK NYDIGAALDT IQYSKHPPPL
Clone 2C11
Isotype IgG2a kappa
 Réactivité croisée Humain, Souris
Plasmids, Primers & others Plasmids, Primers & others SQSTM1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation SQSTM1 (SQSTM1 Antibody Extrait)
Sujet Full Gene Name: sequestosome 1
Synonyms: A170,OSIL,PDB3,ZIP3,p60,p62,p62B
ID gène 8878
Pathways Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Autophagy
Indications d'application Optimal working dilution should be determined by the investigator.
Commentaires

Product Quality tested by: Antibody Reactive Against Recombinant Protein.

Restrictions For Research Use only
Buffer In 1x PBS, pH 7.4
Conseil sur la manipulation Aliquot to avoid repeated freezing and thawing.
Stock -20 °C
Stockage commentaire Store at -20 °C or lower. Aliquot to avoid repeated freezing and thawing.
Images (Fournisseur)
Immunofluorescence (IF) image for anti-Sequestosome 1 (SQSTM1) (AA 1-440), (full length) antibody (ABIN563860) Immunofluorescence of monoclonal antibody to SQSTM1 on HeLa cell. [antibody concentra...
ELISA image for anti-Sequestosome 1 (SQSTM1) (AA 1-440), (full length) antibody (ABIN563860) Detection limit for recombinant GST tagged SQSTM1 is approximately 0.03ng/ml as a cap...
 image for anti-Sequestosome 1 (SQSTM1) (AA 1-440), (full length) antibody (ABIN563860) Western Blot detection against Immunogen (74.14 KDa) .
Produit citée dans: Korwitz, Merkwirth, Richter-Dennerlein, Tröder, Sprenger, Quirós, López-Otín, Rugarli, Langer: "Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria." dans: The Journal of cell biology, Vol. 212, Issue 2, pp. 157-66, 2016 (PubMed).

Sydow, Hochgräfe, Könen, Cadinu, Matenia, Petrova, Joseph, Dennissen, Mandelkow: "Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD." dans: Acta neuropathologica communications, Vol. 4, pp. 17, 2016 (PubMed).

Winner, Beard, Hassiotis, Lau, Luck, Hopwood, Hemsley: "A Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome." dans: Human gene therapy, Vol. 27, Issue 5, pp. 363-75, 2016 (PubMed).

He, Hamm, Reddy, Sams, Peliciari-Garcia, McGinnis, Bailey, Chow, Rowe, Chatham, Young: "Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism." dans: American journal of physiology. Heart and circulatory physiology, Vol. 310, Issue 11, pp. H1520-32, 2016 (PubMed).

Jin, Hong, Park, Chang, Hong, Park, Lee: "Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors." dans: Scientific reports, Vol. 6, pp. 28945, 2016 (PubMed).

Aydinlik, Erkisa, Cevatemre, Sarimahmut, Dere, Ari, Ulukaya: "Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line." dans: Biochimica et biophysica acta, Vol. 1861, Issue 2, pp. 49-57, 2016 (PubMed).

Redmann, Benavides, Berryhill, Wani, Ouyang, Johnson, Ravi, Barnes, Darley-Usmar, Zhang: "Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons." dans: Redox biology, Vol. 11, pp. 73-81, 2016 (PubMed).

Garofalo, Iovine, Kuryk, Capasso, Hirvinen, Vitale, Yliperttula, Bevilacqua, Cerullo: "Oncolytic Adenovirus Loaded with L-carnosine as Novel Strategy to Enhance the Antitumor Activity." dans: Molecular cancer therapeutics, Vol. 15, Issue 4, pp. 651-60, 2016 (PubMed).

Morgan, Thorburn: "Measuring Autophagy in the Context of Cancer." dans: Advances in experimental medicine and biology, Vol. 899, pp. 121-43, 2016 (PubMed).

Wilson, Nikolic, Kentish, Shalini, Hatzinikolas, Page, Dorstyn, Kumar: "Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice." dans: Cell death discovery, Vol. 2, pp. 16009, 2016 (PubMed).

Conlon, Thomas, Fedotova, Hernandez-Ono, Di Paolo, Chan, Ruggles, Gibeley, Liu, Ginsberg: "Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis." dans: The Journal of clinical investigation, Vol. 126, Issue 10, pp. 3852-3867, 2016 (PubMed).

de Luxán-Delgado, Caballero, Potes, Rubio-González, Rodríguez, Gutiérrez-Rodríguez, Solano, Coto-Montes: "Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation." dans: Journal of pineal research, Vol. 56, Issue 2, pp. 126-33, 2015 (PubMed).

Niso-Santano, Malik, Pietrocola, Bravo-San Pedro, Mariño, Cianfanelli, Ben-Younès, Troncoso, Markaki, Sica, Izzo, Chaba, Bauvy, Dupont, Kepp, Rockenfeller, Wolinski, Madeo, Lavandero, Codogno, Harper et al.: "Unsaturated fatty acids induce non-canonical autophagy. ..." dans: The EMBO journal, 2015 (PubMed).

Kucukgul, Ozler, Inci, Karakas, Irmak, Gozuacik, Taralp, Koc: "3D bioprinting of biomimetic aortic vascular constructs with self-supporting cells." dans: Biotechnology and bioengineering, Vol. 112, Issue 4, pp. 811-21, 2015 (PubMed).

Li, Shi, He, Hu, Wang, Zhang, Chan, Chen: "Streptococcus pneumoniae induces autophagy through the inhibition of the PI3K-I/Akt/mTOR pathway and ROS hypergeneration in A549 cells." dans: PLoS ONE, Vol. 10, Issue 3, pp. e0122753, 2015 (PubMed).

Porta, Kwong, Trojanowski, Lee: "Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases." dans: Journal of neuropathology and experimental neurology, Vol. 74, Issue 4, pp. 380-7, 2015 (PubMed).

Yang, Peng, Ni, Li, Shi, Ding, Fan: "Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth." dans: PLoS ONE, Vol. 10, Issue 6, pp. e0130953, 2015 (PubMed).

Dou, Xu, Donahue, Shimi, Pan, Zhu, Ivanov, Capell, Drake, Shah, Catanzaro, Ricketts, Lamark, Adam, Marmorstein, Zong, Johansen, Goldman, Adams, Berger: "Autophagy mediates degradation of nuclear lamina." dans: Nature, Vol. 527, Issue 7576, pp. 105-9, 2015 (PubMed).

Cinque, Forrester, Bartolomeo, Svelto, Venditti, Montefusco, Polishchuk, Nusco, Rossi, Medina, Polishchuk, De Matteis, Settembre: "FGF signalling regulates bone growth through autophagy." dans: Nature, Vol. 528, Issue 7581, pp. 272-5, 2015 (PubMed).

Tung, Wang, Hsu, Hu, Her, Huang, Liao: "Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation." dans: Molecular neurobiology, Vol. 49, Issue 1, pp. 10-27, 2014 (PubMed).

Avez-vous cherché autre chose?