TAP2 anticorps (AA 100-134)

N° du produit ABIN5647692

Détail du produit anti-TAP2 anticorps

Antigène: TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))

Épitope: AA 100-134

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAP2 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 100-134 from human TAP2 was used as the immunogen for the TAP2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the TAP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. WB: 1:1000-1:2000

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the TAP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur TAP2

Antigène: TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))

Autre désignation: TAP2 / ABCB3 (TAP2 Produits)

Synonymes: anticorps ABC18, anticorps ABCB3, anticorps APT2, anticorps D6S217E, anticorps PSF-2, anticorps PSF2, anticorps RING11, anticorps AI462429, anticorps Abcb3, anticorps Ham-2, anticorps Ham2, anticorps MTP2, anticorps Tap-2, anticorps Y1, anticorps jas, anticorps Cim, anticorps transporter 2, ATP binding cassette subfamily B member, anticorps transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), anticorps TAP2, anticorps Tap2

Sujet: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

UniProt: Q03519

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process