PARK7/DJ1 anticorps

N° du produit ABIN5647860

Détail du produit anti-PARK7/DJ1 anticorps

Antigène: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARK7/DJ1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogène: A recombinant rat protein corresponding to amino acids A2-D189 was used as the immunogen for the Park7 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Park7 antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,Direct ELISA (recombinant rat protein): 0.1-0.5 μg/mL (BSA-free format available)

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Park7 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur PARK7/DJ1

Antigène: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Autre désignation: DJ-1 / Park7 (PARK7 Produits)

Synonymes: anticorps DJ-1, anticorps DJ1, anticorps CAP1, anticorps Dj1, anticorps SP22, anticorps dj1, anticorps zgc:103725, anticorps park7b, anticorps park7, anticorps park7a, anticorps Parkinsonism associated deglycase, anticorps Parkinson disease (autosomal recessive, early onset) 7, anticorps parkinson protein 7, anticorps parkinson protein 7 S homeolog, anticorps parkinson protein 7 L homeolog, anticorps PARK7, anticorps Park7, anticorps park7, anticorps park7.S, anticorps park7.L

Sujet: Parkinson disease (autosomal recessive, early onset) 7, also known as DJ1, is a protein which in humans is encoded by the PARK7 gene. PARK7 belongs to the peptidase C56 family of proteins. PARK7 is mapped to chromosome 1p36. It acts as a positive regulator of androgen receptor-dependent transcription. It is also involved in tumorigenesis and in maintaining mitochondrial homeostasis. This gene may also function as a redox-sensitive chaperone, as a sensor foroxidative stress, and it apparently protects neurons against oxidative stress and cell death. It has been found that PARK7 mutations that impair transcriptional coactivator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease.

UniProt: O88767

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport