R-Spondin 3 anticorps (AA 214-248)

N° du produit ABIN5647910

Détail du produit anti-R-Spondin 3 anticorps

Antigène: R-Spondin 3 (RSPO3)

Épitope: AA 214-248

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp R-Spondin 3 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 214-248 from the human protein was used as the immunogen for the RSPO3 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western blot: 1:1000-2000

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the RSPO3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur R-Spondin 3

Antigène: R-Spondin 3 (RSPO3)

Autre désignation: RSPO3 / R-spondin 3 (RSPO3 Produits)

Synonymes: anticorps pwtsr, anticorps thsd2, anticorps cristin1, anticorps CRISTIN1, anticorps PWTSR, anticorps THSD2, anticorps RGD1563246, anticorps 2810459H04Rik, anticorps AW742308, anticorps Cristin1, anticorps Thsd2, anticorps R-spondin 3, anticorps rspo3, anticorps RSPO3, anticorps Rspo3

Sujet: R-spondin-3 is an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

ID gène: 84870

UniProt: Q9BXY4