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ALKBH7 anticorps (AA 1-221)

ALKBH7 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5664063
  • Antigène Voir toutes ALKBH7 Anticorps
    ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
    Épitope
    AA 1-221
    Reactivité
    • 9
    • 8
    • 1
    Humain
    Hôte
    • 9
    Lapin
    Clonalité
    • 9
    Polyclonal
    Conjugué
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ALKBH7 est non-conjugé
    Application
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Séquence
    MAGTGLLALR TLPGPSWVRG SGPSVLSRLQ DAAVVRPGFL STAEEETLSR ELEPELRRRR YEYDHWDAAI HGFRETEKSR WSEASRAILQ RVQAAAFGPG QTLLSSVHVL DLEARGYIKP HVDSIKFCGA TIAGLSLLSP SVMRLVHTQE PGEWLELLLE PGSLYILRGS ARYDFSHEIL RDEESFFGER RIPRGRRISV ICRSLPEGMG PGESGQPPPA C
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human ALKBH7 (NP_115682.1).
    Isotype
    IgG
  • Indications d'application
    WB,1:200 - 1:2000
    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
    Autre désignation
    ALKBH7 (ALKBH7 Produits)
    Synonymes
    anticorps ABH7, anticorps SPATA11, anticorps UNQ6002, anticorps 2310045B01Rik, anticorps 2510008E23Rik, anticorps Abh7, anticorps Spata11, anticorps alkB homolog 7, anticorps Alkbh7, anticorps ALKBH7
    Sujet
    May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110 (in vitro, but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity.,ALKBH7,ABH7,SPATA11,UNQ6002,Epigenetics & Nuclear Signaling,DNA Damage & Repair,ALKBH7
    Poids moléculaire
    24 kDa
    ID gène
    84266
    UniProt
    Q9BT30
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