CRBN anticorps (C-Term)

N° du produit ABIN5689929

Détail du produit anti-CRBN anticorps

Antigène: CRBN (Cereblon (CRBN))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRBN est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: CRBN antibody is human, mouse and rat reactive. At least two isoforms of CRBN are known to exist, this antibody will detect both isoforms.

Purification: CRBN antibody is affinity chromatography purified via peptide column.

Immunogène: CRBN antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRBN.

The immunogen is located within the last 50 amino acids of CRBN.

Isotype: IgG

Information d'application

Indications d'application: CRBN antibody can be used for detection of CRBN by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CRBN antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: CRBN antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur CRBN

Antigène: CRBN (Cereblon (CRBN))

Autre désignation: CRBN (CRBN Produits)

Synonymes: anticorps zgc:92404, anticorps mrt2a, anticorps F3N11.21, anticorps MRT2, anticorps MRT2A, anticorps 2610203G15Rik, anticorps 2900045O07Rik, anticorps AF229032, anticorps AW108261, anticorps piL, anticorps cereblon, anticorps ATP-dependent protease La (LON) domain protein, anticorps crbn, anticorps CRBN, anticorps AT2G25740, anticorps Crbn

Sujet: CRBN, a member of the Lon protease protein family, plays a role in brain development (1). It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8 (2). CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain (3,4).

Poids moléculaire: Predicted: 49 kDa

Observed: 54 kDa

ID gène: 51185

NCBI Accession: NP_057386

UniProt: Q96SW2