Deltex Homolog 4 anticorps (AA 230-280)

N° du produit ABIN5689952

Détail du produit anti-Deltex Homolog 4 anticorps

Antigène: Deltex Homolog 4 (DTX4) (Deltex Homolog 4 (Drosophila) (DTX4))

Épitope: AA 230-280

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Deltex Homolog 4 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: DTX4 antibody is human and mouse reactive. At least two isoforms of DTX4 are known to exist, this antibody will detect both isoforms. DTX4 antibody is predicted to not cross-react with other DTX protein family members.

Purification: DTX4 antibody is affinity chromatography purified via peptide column.

Immunogène: DTX4 antibody was raised against a 19 amino acid peptide near the center of human DTX4.

The immunogen is located within amino acids 230 - 280 of DTX4.

Isotype: IgG

Information d'application

Indications d'application: DTX4 antibody can be used for detection of DTX4 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: DTX4 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: DTX4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur Deltex Homolog 4

Antigène: Deltex Homolog 4 (DTX4) (Deltex Homolog 4 (Drosophila) (DTX4))

Autre désignation: DTX4 (DTX4 Produits)

Synonymes: anticorps RNF155, anticorps AI449438, anticorps BC044798, anticorps D930042H13, anticorps zgc:163052, anticorps LRRGT00037, anticorps deltex E3 ubiquitin ligase 4, anticorps deltex 4, E3 ubiquitin ligase, anticorps DTX4, anticorps Dtx4, anticorps dtx4

Sujet: The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis (1). Recent studies have shown that DTX4 is also associated with the innate immune response (2). Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity (2).

Poids moléculaire: Predicted: 68 kDa

Observed: 68 kDa

ID gène: 23220

NCBI Accession: NP_055992

UniProt: Q9Y2E6

Pathways: Signalisation Notch