JAGN1 anticorps (C-Term)

N° du produit ABIN5690022

Détail du produit anti-JAGN1 anticorps

Antigène: JAGN1 (Jagunal Homolog 1 (JAGN1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JAGN1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: JAGN1 antibody is human, mouse and rat reactive. At least four isoforms of JAGN1 are known to exist, this antibody will detect all but isoform 2.

Purification: JAGN1 antibody is affinity chromatography purified via peptide column.

Immunogène: JAGN1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAGN1.

The immunogen is located within the last 50 amino acids of JAGN1.

Isotype: IgG

Information d'application

Indications d'application: JAGN1 antibody can be used for detection of JAGN1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: JAGN1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: JAGN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur JAGN1

Antigène: JAGN1 (Jagunal Homolog 1 (JAGN1))

Autre désignation: JAGN1 (JAGN1 Produits)

Synonymes: anticorps GL009, anticorps 5830427H10Rik, anticorps zgc:101070, anticorps wu:fb07b07, anticorps zgc:101045, anticorps jagunal homolog 1, anticorps jagunal homolog 1 L homeolog, anticorps jagunal homolog 1a, anticorps jagunal homolog 1b, anticorps JAGN1, anticorps Jagn1, anticorps jagn1.L, anticorps jagn1a, anticorps jagn1b

Sujet: JAGN1 is the human ortholog of a gene originally identified in Drosophila melanogaster. It is a transmembrane protein that functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Individuals with mutations in the JAGN1 gene causes aberrant myeloid cell homeostasis and severe congenital neutropenia (SCN) (1). JAGN1-mutant granulocytes are characterized by ultrastructural defects, aberrant N-glycosylation of multiple proteins, and increased apoptosis (1). Mice lacking this gene could not mount and efficient neutrophil-dependent immune response to a human fungal pathogen (2).

Poids moléculaire: Predicted: 20 kDa

Observed: 25 kDa

ID gène: 84522

NCBI Accession: NP_115881

UniProt: Q8N5M9