COL4A1 anticorps (AA 1445-1669)

N° du produit ABIN5692826

Détail du produit anti-COL4A1 anticorps

Antigène: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Épitope: AA 1445-1669

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp COL4A1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Marque: Picoband™

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Mouse IgG monoclonal antibody for Collagen IV detection. Tested with WB, IHC-P in Human.

Immunogène: E.coli-derived human Collagen IV recombinant protein (Position: G1445-T1669). Human Collagen IV shares 97% amino acid (aa) sequence identity with mouse Collagen IV.

Clone: 3G3

Isotype: IgG1

Information d'application

Indications d'application:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Application Details: Western blot, 0.1-0.5 μg/mL
Immunohistochemistry(Paraffin-embedded Section), 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-COL4A1 (ABIN5692826)

Li, Xiao, Li, Li, Zeng, Liu, Liang, Li, Chu, Yang: "Hydrogen sulfide reduced renal tissue fibrosis by regulating autophagy in diabetic rats." dans: Molecular medicine reports, Vol. 16, Issue 2, pp. 1715-1722, (2018) (PubMed).

Zhang, Ju, Nie, Song, Xu, Gao: "Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells." dans: International journal of molecular medicine, Vol. 42, Issue 1, pp. 279-289, (2018) (PubMed).

Zhang, Jin, Tian, Wu: "hsa-miR-29c-3p regulates biological function of colorectal cancer by targeting SPARC." dans: Oncotarget, Vol. 8, Issue 61, pp. 104508-104524, (2017) (PubMed).

Fan, Jiang, Li, Fang, Xu, Zheng: "MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elastic fibers correlate with disease progression in a hamster model of tongue cancer." dans: Oncology letters, Vol. 11, Issue 1, pp. 63-68, (2016) (PubMed).

Zhang, Teng, Liu, Zhang, Liu: "Gene expression profile analyze the molecular mechanism of CXCR7 regulating papillary thyroid carcinoma growth and metastasis." dans: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 16, (2015) (PubMed).

Zhu, Xu, Yuan, Guo, Liu: "Transcriptome sequencing reveals differences between primary and secondary hair follicle-derived dermal papilla cells of the Cashmere goat (Capra hircus)." dans: PLoS ONE, Vol. 8, Issue 9, pp. e76282, (2013) (PubMed).

Wen, Huang, Zhang, Zhang, Chen, Gu, Hao: "Resveratrol attenuates diabetic nephropathy via modulating angiogenesis." dans: PLoS ONE, Vol. 8, Issue 12, pp. e82336, (2013) (PubMed).

Zhou, Li, Cai: "Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway." dans: The American journal of pathology, Vol. 165, Issue 6, pp. 2033-43, (2005) (PubMed).

Détails sur COL4A1

Antigène: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Autre désignation: COL4A1 (COL4A1 Produits)

Synonymes: anticorps col4a1, anticorps wu:fc02g11, anticorps HANAC, anticorps ICH, anticorps POREN1, anticorps arresten, anticorps Bru, anticorps Col4a-1, anticorps Del(8)44H, anticorps Raw, anticorps Svc, anticorps collagen, type IV, alpha 5 (Alport syndrome), anticorps collagen type IV alpha 1 chain, anticorps collagen, type IV, alpha 1, anticorps col4a5, anticorps COL4A1, anticorps Col4a1

Sujet:

Synonyms: Collagen alpha-1(IV) chain, Arresten, COL4A1

Tissue Specificity: Highly expressed in placenta.

Background: COL4A1, also known as ICH or Collagen alpha-1(IV), is a protein that in humans is encoded by the COL4A1 gene. It is mapped to 13q34. This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. COL4A1 binds to alpha-1/beta-1 integrin and inhibits migration, proliferation, and tube formation by endothelial cells. It is also a potential therapeutic candidate for targeting tumor angiogenesis.

UniProt: P02462

Pathways: Skeletal Muscle Fiber Development, Growth Factor Binding