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INPP5D anticorps

INPP5D Reactivité: Humain, Souris, Rat WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5693121
  • Antigène Voir toutes INPP5D Anticorps
    INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
    Reactivité
    • 87
    • 61
    • 37
    • 20
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 83
    • 5
    Lapin
    Clonalité
    • 71
    • 17
    Polyclonal
    Conjugué
    • 35
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp INPP5D est non-conjugé
    Application
    • 61
    • 21
    • 18
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Marque
    Picoband™
    Séquence
    NEDDKFTVQA SEGVSMRFFT KLDQLIEFYK KENMGLVTHL Q
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for SHIP detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Immunogène
    A synthetic peptide corresponding to a sequence of human SHIP (NEDDKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQ).
    Top Product
    Discover our top product INPP5D Anticorps primaire
  • Indications d'application

    Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

    Application Details: Western blot,0.1-0.5 μg/mL
    Immunohistochemistry(Paraffin-embedded Section),0.5-1 μg/mL

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
  • Antigène
    INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
    Autre désignation
    INPP5D (INPP5D Produits)
    Synonymes
    anticorps INPP5D, anticorps 256.t00004, anticorps 13.t00027, anticorps ship, anticorps ship1, anticorps AI323613, anticorps SHIP, anticorps SHIP-1, anticorps SHIP1, anticorps s-SHIP, anticorps SIP-145, anticorps hp51CN, anticorps inositol polyphosphate-5-phosphatase D, anticorps phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, anticorps inositol polyphosphate 5-phosphatase, anticorps inositol polyphosphate-5-phosphatase D L homeolog, anticorps INPP5D, anticorps LOC100446045, anticorps inpp5d, anticorps EHI_159880, anticorps EHI_153490, anticorps inpp5d.L, anticorps LOC100380693, anticorps Inpp5d
    Sujet

    Synonyms: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D, SHIP, SHIP1

    Tissue Specificity: Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74 % of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10 % of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level).

    Background: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 is an enzyme that in humans is encoded by the INPP5D gene. This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system.

    UniProt
    Q92835
    Pathways
    TCR Signaling, BCR Signaling, L'effet Warburg
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