ADO anticorps (AA 49-261) (DyLight 488)

N° du produit ABIN7354745

Détail du produit anti-ADO anticorps (DyLight 488)

Antigène: ADO (2-Aminoethanethiol (Cysteamine) Dioxygenase (ADO))

Épitope: AA 49-261

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADO est conjugé à/à la DyLight 488

Application: Flow Cytometry (FACS)

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG Polyclonal Anti-Human ADO Antibody DyLight® 488 Conjugated, Flow Validated.

Immunogène: E. coli-derived human ADO recombinant protein (Position: E49-E261). Human ADO shares 90.1% amino acid (aa) sequence identity with mouse ADO.

Information d'application

Indications d'application:

Application Details: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: At 2-8°C for one year. Protect from light. Do not freeze.

Détails sur ADO

Antigène: ADO (2-Aminoethanethiol (Cysteamine) Dioxygenase (ADO))

Autre désignation: ADO (ADO Produits)

Synonymes: anticorps C10orf22, anticorps Gm237, anticorps RGD1308233, anticorps wu:fc32g01, anticorps wu:fc52c12, anticorps zgc:101580, anticorps 2-aminoethanethiol dioxygenase, anticorps 2-aminoethanethiol (cysteamine) dioxygenase, anticorps 2-aminoethanethiol (cysteamine) dioxygenase a, anticorps ADO, anticorps Ado, anticorps LOC100351598, anticorps adoa

Sujet:

Synonyms: 2-aminoethanethiol dioxygenase, Cysteamine dioxygenase, ADO, C10orf22

Background: Human thiol dioxygenases include cysteine dioxygenase (CDO) and cysteamine (2-aminoethanethiol) dioxygenase (ADO). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine. It is demonstrated that mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine. Recombinant Ado was shown to bind iron. Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine. Similar results were found with human ADO. When endogenous expression of ADO was reduced by RNA-mediated interference, hypotaurine production decreased. It is also noted that the demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity.