Caspase 3 anticorps (AA 67-175) (DyLight 488)

N° du produit ABIN7354496

Détail du produit anti-Caspase 3 anticorps (DyLight 488)

Antigène: Caspase 3 (CASP3)

Épitope: AA 67-175

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 3 est conjugé à/à la DyLight 488

Application: Flow Cytometry (FACS)

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG Polyclonal Anti-Human Caspase-3 Antibody DyLight® 488 Conjugated, Flow Validated.

Immunogène: E.coli-derived human Caspase-3 recombinant protein (Position: T67-D175). Human Caspase-3 shares 86% and 90% amino acid (aa) sequence identity with mouse and rat Caspase-3, respectively.

Information d'application

Indications d'application:

Application Details: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: At 2-8°C for one year. Protect from light. Do not freeze.

Références pour anticorps anti-Caspase 3 (DyLight 488) (ABIN7354496)

Bai, Yang, Luo: "Effects of 5-hydroxy-4'-nitro-7-propionyloxy-genistein on inhibiting proliferation and invasion via activating reactive oxygen species in human ovarian cancer A2780/DDP cells." dans: Oncology letters, Vol. 15, Issue 4, pp. 5227-5235, (2018) (PubMed).

Yang, Shi, Soomro, Hu, Du, She: "Hepatitis E Virus Induces Hepatocyte Apoptosis via Mitochondrial Pathway in Mongolian Gerbils." dans: Frontiers in microbiology, Vol. 9, pp. 460, (2018) (PubMed).

Qi, Xue, Lv, Sun, Du, Cai, Li, Gu, Wang: "Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway." dans: Oncology letters, Vol. 15, Issue 5, pp. 6400-6408, (2018) (PubMed).

Xu, Xie, Wang, Wang, Luo, Zhou, Wang, Huang, Tan, Jin, Qi, Tang, Chen, Du, Zhao, Liang, Chen: "A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis." dans: Scientific reports, Vol. 6, pp. 24042, (2017) (PubMed).

Hu, Sun, Zhang, Zhang, Hu: "Catalpol inhibits apoptosis in hydrogen peroxide-induced cardiac myocytes through a mitochondrial-dependent caspase pathway." dans: Bioscience reports, Vol. 36, Issue 3, (2017) (PubMed).

Zhou, He, Wang, Xie, Liu, Liu, Song, Ma: "Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therapy Using the Bifidobacterium-Mediated Recombinant HSV-1 Thymidine Kinase and Ganciclovir." dans: International journal of molecular sciences, Vol. 17, Issue 6, (2017) (PubMed).

Xu, Tan, Jiang, Chen, Lai, Zhang, Liang: "Effects of Bushen Tianjing Recipe in a rat model of tripterygium glycoside-induced premature ovarian failure." dans: Chinese medicine, Vol. 12, pp. 10, (2017) (PubMed).

Zheng, Chen, Zhu, Li, Deng, Wang, Zhang, Chen: "Liraglutide prevents fast weight gain and β-cell dysfunction in male catch-up growth rats." dans: Experimental biology and medicine (Maywood, N.J.), Vol. 240, Issue 9, pp. 1165-76, (2016) (PubMed).

Han, Liu, Li, Tian, Han, Wang, Fu, Guo, Zhu, Du, Tian: "HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma." dans: PLoS ONE, Vol. 10, Issue 11, pp. e0142387, (2016) (PubMed).

Ji, Geng, Zhou, Wei, Chen: "Chinese herbal medicine Yougui Pill reduces exogenous glucocorticoid-induced apoptosis in anterior pituitary cells." dans: Neural regeneration research, Vol. 11, Issue 12, pp. 1962-1968, (2016) (PubMed).

Shi, Liu, Ren, Mao, Tan, Ding, Yang, Li: "Nutlin-3 downregulates p53 phosphorylation on serine392 and induces apoptosis in hepatocellular carcinoma cells." dans: BMB reports, Vol. 47, Issue 4, pp. 221-6, (2015) (PubMed).

Guan, Zheng, Huang, Li, Niu, Liu: "Powerful inner/outer controlled multi-target magnetic nanoparticle drug carrier prepared by liquid photo-immobilization." dans: Scientific reports, Vol. 4, pp. 4990, (2015) (PubMed).

Chen, Li, Xu, Zhang, Tao, Li, Jiang, Shen: "Essential Oils from Fructus A. zerumbet Protect Human Aortic Endothelial Cells from Apoptosis Induced by Ox-LDL In Vitro." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 956824, (2015) (PubMed).

Hui, Yuan, Ren, Jiang: "Nerve growth factor reduces apoptotic cell death in rat facial motor neurons after facial nerve injury." dans: Neurosciences (Riyadh, Saudi Arabia), Vol. 20, Issue 1, pp. 65-8, (2015) (PubMed).

Xu, Liu, Zhang, Wang, Wang, Yang, Huo, Sun: "Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy." dans: Neural regeneration research, Vol. 7, Issue 17, pp. 1318-24, (2015) (PubMed).

Wu, Wang, Hou: "Alpha B-crystallin improved survival of retinal ganglion cells in a rat model of acute ocular hypertension." dans: Neural regeneration research, Vol. 7, Issue 19, pp. 1493-7, (2015) (PubMed).

Lu, Yuan, Ou, Cai, Wang, Sun, Zhang: "Autophagy and apoptosis during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro." dans: Neural regeneration research, Vol. 7, Issue 16, pp. 1205-12, (2015) (PubMed).

Wang, Qu, Zhang, Zhang: "Testosterone suppresses ventricular remodeling and improves left ventricular function in rats following myocardial infarction." dans: Experimental and therapeutic medicine, Vol. 9, Issue 4, pp. 1283-1291, (2015) (PubMed).

Li, Zhao, Xing, Sun: "Ulinastatin suppresses endoplasmic reticulum stress and apoptosis in the hippocampus of rats with acute paraquat poisoning." dans: Neural regeneration research, Vol. 10, Issue 3, pp. 467-72, (2015) (PubMed).

Du, Ding, Zou, Li, Tian, She, Wang, Wang, Lv, Chang: "Morphology and Molecular Mechanisms of Hepatic Injury in Rats under Simulated Weightlessness and the Protective Effects of Resistance Training." dans: PLoS ONE, Vol. 10, Issue 5, pp. e0127047, (2015) (PubMed).

Détails sur Caspase 3

Antigène: Caspase 3 (CASP3)

Autre désignation: CASP3 (CASP3 Produits)

Synonymes: anticorps CPP32, anticorps CPP32B, anticorps SCA-1, anticorps A830040C14Rik, anticorps AC-3, anticorps Apopain, anticorps CC3, anticorps Caspase-3, anticorps Lice, anticorps Yama, anticorps mldy, anticorps xcpp32, anticorps casp3, anticorps zgc:100890, anticorps CASP-3, anticorps caspase-3, anticorps caspase 3, anticorps caspase 3 S homeolog, anticorps caspase 3, apoptosis-related cysteine peptidase a, anticorps caspase 3, apoptosis-related cysteine peptidase, anticorps CASP3, anticorps Casp3, anticorps casp3.S, anticorps casp3a

Sujet:

Synonyms: Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, CASP3, CPP32

Tissue Specificity: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.

Background: Caspase 3 is a caspase protein which interacts with Survivin, XIAP, CFLAR, Caspase 8, HCLS1, Deleted in Colorectal Cancer, TRAF3 and GroEL. This gene which is located on 4q35 encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. And the caspase-3 activation in heart failure sequentially cleaves SRF and generates a truncated SRF that appears to function as a dominant-negative transcription factor. Additionally, the caspase-3 influence on bone mineral density should be considered in any in vivo application of caspase-3 inhibitors to the treatment of human disease. In erythroid precursors undergoing terminal differentiation, Hsp70 prevents active CASP3 from cleaving GATA1 and inducing apoptosis.

UniProt: P42574

Pathways: Apoptose, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation