OAS3 anticorps

N° du produit ABIN5696851

Détail du produit anti-OAS3 anticorps

Antigène: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OAS3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Immunogène: 2'-5'-oligoadenylate synthetase 3, 100kDa

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

A375 cells were subjected to SDS PAGE followed by western blot with FNab05952(OAS3 antibody) at dilution of 1:800

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur OAS3

Antigène: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Autre désignation: OAS3 (OAS3 Produits)

Synonymes: anticorps p100, anticorps Oasl10, anticorps 2'-5'-oligoadenylate synthetase 3, anticorps 2'-5' oligoadenylate synthetase 3, anticorps OAS3, anticorps Oas3

Sujet: Synonyms: Background:Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus(CHIKV), Dengue virus, Sindbis virus(SINV) and Semliki forest virus(SFV).

Poids moléculaire: 100 kDa

ID gène: 4940

UniProt: Q9Y6K5

Pathways: Hepatitis C