Spastin anticorps

N° du produit ABIN5698478

Détail du produit anti-Spastin anticorps

Antigène: Spastin (SPAST)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Spastin est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: spastin

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur Spastin

Antigène: Spastin (SPAST)

Autre désignation: SPAST (SPAST Produits)

Synonymes: anticorps CG5977, anticorps D-spastin, anticorps Dmel\\CG5977, anticorps Dspastin, anticorps Spas, anticorps zgc:85952, anticorps SPAST, anticorps spg4, anticorps LOC100224472, anticorps ADPSP, anticorps FSP2, anticorps SPG4, anticorps Spg4, anticorps mKIAA1083, anticorps spastin, anticorps spastin S homeolog, anticorps spas, anticorps spast, anticorps SPAST, anticorps Spast, anticorps spast.S

Sujet: Synonyms:Kiaa1083, Spg4 Background:ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated(PubMed:19141076 PubMed:20530212). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold(By similarity). Severing activity is not dependent on tubulin acetylation or detyrosination(By similarity). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation(By similarity). It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia(By similarity). SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex(By similarity). Recruited at the midbody, probably by IST1, and participates to membrane fission during abscission together with the ESCRT-III complex(By similarity). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase(By similarity). Required for membrane traffic from the endoplasmic reticulum(ER) to the Golgi and endosome recycling(By similarity). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing(By similarity). Probably plays a role in axon growth and the formation of axonal branches(PubMed:18234839). Isoform 1: Involved in lipid metabolism by regulating the size and distribution of lipid droplets.

ID gène: 50850

UniProt: Q9QYY8

Pathways: Dynamique des Microtubules, M Phase, Regulation of Cell Size