OAS2 anticorps

N° du produit ABIN5700165

Détail du produit anti-OAS2 anticorps

Antigène: OAS2 (2'-5'-Oligoadenylate Synthetase 2, 69/71kDa (OAS2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OAS2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Immunogène: 2'-5'-oligoadenylate synthetase 2, 69/71kDa

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab05951(OAS2 antibody) at dilution of 1:500

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur OAS2

Antigène: OAS2 (2'-5'-Oligoadenylate Synthetase 2, 69/71kDa (OAS2))

Autre désignation: OAS2 (OAS2 Produits)

Synonymes: anticorps Oasl11, anticorps 2'-5'-oligoadenylate synthetase 2, anticorps 2'-5' oligoadenylate synthetase 2, anticorps 2'-5'-oligoadenylate synthetase 2, 69/71kDa, anticorps OAS2, anticorps Oas2

Sujet: Synonyms: Background:Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.

Poids moléculaire: 66-71 kDa

ID gène: 4939

UniProt: P29728

Pathways: Hepatitis C