FBXO9 anticorps

N° du produit ABIN5700868

Détail du produit anti-FBXO9 anticorps

Antigène: FBXO9 (F-Box Protein 9 (FBXO9))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXO9 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogène: F-box protein 9

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

human liver tissue were subjected to SDS PAGE followed by western blot with FNab03051(FBXO9 antibody) at dilution of 1:300

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur FBXO9

Antigène: FBXO9 (F-Box Protein 9 (FBXO9))

Autre désignation: FBXO9 (FBXO9 Produits)

Synonymes: anticorps fbxo9, anticorps MGC75727, anticorps FBXO9, anticorps fbx9, anticorps FBX9, anticorps NY-REN-57, anticorps VCIA1, anticorps dJ341E18.2, anticorps wu:fc79g12, anticorps zgc:56212, anticorps zgc:77654, anticorps 9030401P18Rik, anticorps AA986398, anticorps F-box protein 9, anticorps F-box only protein 9, anticorps f-box protein 9, anticorps F-box protein 9 L homeolog, anticorps fbxo9, anticorps FBXO9, anticorps CpipJ_CPIJ012920, anticorps Tsp_03945, anticorps fbx9, anticorps Fbxo9, anticorps fbxo9.L

Sujet: Synonyms:FBX9, VCIA1 Background:Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

Poids moléculaire: 52 kDa

ID gène: 26268

UniProt: Q9UK97