VPS33A anticorps

N° du produit ABIN5701413

Détail du produit anti-VPS33A anticorps

Antigène: VPS33A (Vacuolar Protein Sorting 33 Homolog A (VPS33A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS33A est non-conjugé

Application: ELISA, Western Blotting (WB)

Immunogène: vacuolar protein sorting 33 homolog A (S. cerevisiae)

Isotype: IgG

Information d'application

Indications d'application: WB :1:500-1:5000,IP:1:200-1:2000

Commentaires:

human brain tissue were subjected to SDS PAGE followed by western blot with FNab09435(VPS33A antibody) at dilution of 1:500

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur VPS33A

Antigène: VPS33A (Vacuolar Protein Sorting 33 Homolog A (VPS33A))

Autre désignation: VPS33A (VPS33A Produits)

Synonymes: anticorps r-Vps33a, anticorps VPS33A, anticorps vps33a, anticorps MGC145524, anticorps 3830421M04Rik, anticorps AI503300, anticorps AW048546, anticorps AW554476, anticorps bf, anticorps im:7136893, anticorps wu:fc08g01, anticorps wu:fc26c10, anticorps VPS33A CORVET/HOPS core subunit, anticorps VPS33A, CORVET/HOPS core subunit, anticorps vacuolar protein sorting 33 homolog A (S. cerevisiae), anticorps Vacuolar protein sorting 33A, anticorps VPS33A, CORVET/HOPS core subunit L homeolog, anticorps vacuolar protein sorting 33A, anticorps Vps33a, anticorps VPS33A, anticorps vps33a, anticorps CGB_E2330C, anticorps vps33a.L

Sujet: Synonyms:FLJ22395, FLJ23187, hVPS33A, VPS33A Background:Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes, the function is dependent on its association with VPS16 but not VIPAS39(PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG(PubMed:24554770).

Poids moléculaire: 28kDa

ID gène: 65082

UniProt: Q96AX1