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CHCHD4 anticorps

CHCHD4 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5701518
  • Antigène Voir toutes CHCHD4 Anticorps
    CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))
    Reactivité
    • 31
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 30
    • 1
    Lapin
    Clonalité
    • 30
    • 1
    Polyclonal
    Conjugué
    • 17
    • 4
    • 3
    • 3
    • 2
    • 2
    Cet anticorp CHCHD4 est non-conjugé
    Application
    • 25
    • 20
    • 18
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Immunogène
    coiled-coil-helix-coiled-coil-helix domain containing 4
    Isotype
    IgG
    Top Product
    Discover our top product CHCHD4 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    rat brain tissue were subjected to SDS PAGE followed by western blot with FNab01637( CHCHD4 Antibody) at dilution of 1:1500

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze / thaw cycles.
    Stock
    -20 °C
    Date de péremption
    12 months
  • Antigène
    CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))
    Autre désignation
    CHCHD4 (CHCHD4 Produits)
    Synonymes
    anticorps 2410012P20Rik, anticorps 2810014D17Rik, anticorps AI838740, anticorps MIA40, anticorps TIMM40, anticorps mia40, anticorps timm40, anticorps chchd4, anticorps chchd4a, anticorps fc10g04, anticorps wu:fc10g04, anticorps zgc:100849, anticorps si:dkey-202e22.1, anticorps chchd4b, anticorps CaO19.2977, anticorps coiled-coil-helix-coiled-coil-helix domain containing 4, anticorps coiled-coil-helix-coiled-coil-helix domain containing 4 L homeolog, anticorps coiled-coil-helix-coiled-coil-helix domain containing 4a, anticorps coiled-coil-helix-coiled-coil-helix domain containing 4 S homeolog, anticorps Mia40p, anticorps Chchd4, anticorps CHCHD4, anticorps chchd4, anticorps chchd4.L, anticorps chchd4a, anticorps chchd4.S, anticorps LOC100361898, anticorps MIA40
    Sujet
    Synonyms:MIA40 Background:Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1(PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364). Required for the import and folding of small cysteine-containing proteins(small Tim) in the mitochondrial intermembrane space(IMS)(PubMed:16185709, PubMed:19182799, PubMed:21059946). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria(PubMed:16185709, PubMed:19182799, PubMed:21059946). The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS(PubMed:16185709, PubMed:19182799, PubMed:21059946). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system(PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake(PubMed:26387864).
    Poids moléculaire
    22-25 kDa
    ID gène
    131474
    UniProt
    Q8N4Q1
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