VPS4B anticorps

N° du produit ABIN5701702

Détail du produit anti-VPS4B anticorps

Antigène: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS4B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Immunogène: vacuolar protein sorting 4 homolog B (S. cerevisiae)

Isotype: IgG

Information d'application

Indications d'application: WB :1:500-1:5000,IP:1:500-1:5000,IF:1:10-1:100

Commentaires:

Y79 cells were subjected to SDS PAGE followed by western blot with FNab09446(VPS4B antibody) at dilution of 1:500

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur VPS4B

Antigène: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Autre désignation: VPS4B (vps4b Produits)

Synonymes: anticorps zgc:63682, anticorps vps4a, anticorps SKD1, anticorps SKD1B, anticorps VPS4-2, anticorps 8030489C12Rik, anticorps Skd1, anticorps vacuolar protein sorting 4 homolog B, anticorps vacuolar protein sorting 4 homolog B S homeolog, anticorps vacuolar protein sorting 4b homolog B (S. cerevisiae), anticorps vacuolar protein sorting 4 homolog B (S. cerevisiae), anticorps vacuolar protein sorting 4B, anticorps Vps4b, anticorps vps4b.S, anticorps vps4b, anticorps VPS4B

Sujet: Synonyms:MIG1, Protein SKD1, SKD1, VPS4 2, VPS42, VPS4B Background:Involved in late steps of the endosomal multivesicular bodies(MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding(HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413).

Poids moléculaire: 49kDa

ID gène: 9525

UniProt: O75351

Pathways: Dynamique des Microtubules, CXCR4-mediated Signaling Events