RWDD3 anticorps

N° du produit ABIN5701924

Détail du produit anti-RWDD3 anticorps

Antigène: RWDD3 (RWD Domain Containing 3 (RWDD3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RWDD3 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Immunogène: RWD domain containing 3

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur RWDD3

Antigène: RWDD3 (RWD Domain Containing 3 (RWDD3))

Autre désignation: RWDD3 (RWDD3 Produits)

Synonymes: anticorps DKFZp469N1913, anticorps RSUME, anticorps 2510027J23Rik, anticorps 3110037C01Rik, anticorps AI035684, anticorps AI662458, anticorps X2CR1, anticorps X2cr1, anticorps zgc:73229, anticorps RWD domain containing 3, anticorps RWDD3, anticorps rwdd3, anticorps Rwdd3

Sujet: Synonyms:RSUME Background:Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha(NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha(HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.

ID gène: 25950

UniProt: Q9Y3V2