AKAP8L anticorps
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- Antigène Voir toutes AKAP8L Anticorps
- AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp AKAP8L est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Immunogène
- A kinase (PRKA) anchor protein 8-like
- Isotype
- IgG
- Top Product
- Discover our top product AKAP8L Anticorps primaire
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- Indications d'application
- WB :1:200-1:2000,IF:1:20-200
- Commentaires
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PC-3 cells were subjected to SDS PAGE followed by western blot with FNab00258( AKAP8L Antibody) at dilution of 1:300
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))
- Autre désignation
- AKAP8L (AKAP8L Produits)
- Synonymes
- anticorps HA95, anticorps HAP95, anticorps NAKAP, anticorps NAKAP95, anticorps Nakap95, anticorps zgc:85966, anticorps AKAP8L, anticorps A-kinase anchoring protein 8 like, anticorps A kinase (PRKA) anchor protein 8-like, anticorps A-kinase anchoring protein 8 like L homeolog, anticorps AKAP8L, anticorps Akap8l, anticorps akap8l, anticorps akap8l.L
- Sujet
- Synonyms:A kinase anchor protein 8 like, AKAP8 like protein, AKAP8L, DKFZp434L0650, HA95, HAP95, Helicase A binding protein 95, Homologous to AKAP95 protein, NAKAP, NAKAP95, Neighbor of AKAP95 Background:Could play a role in constitutive transport element(CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export(PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA(PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis(PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta(PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3, in this function seems to act redundantly with AKAP8(PubMed:16980585). May be involved in regulation of pre-mRNA splicing(PubMed:17594903). (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters(PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses(PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription, in vitro negatively regulates DHX9 annealing activity(PubMed:25034436).
- Poids moléculaire
- 72kDa
- ID gène
- 26993
- UniProt
- Q9ULX6
- Pathways
- SARS-CoV-2 Protein Interactome
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