FBXO6 anticorps
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- Antigène Voir toutes FBXO6 Anticorps
- FBXO6 (F-Box Protein 6 (FBXO6))
- Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FBXO6 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogène
- F-box protein 6
- Isotype
- IgG
- Top Product
- Discover our top product FBXO6 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab03048(FBXO6 antibody) at dilution of 1:300
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- FBXO6 (F-Box Protein 6 (FBXO6))
- Autre désignation
- FBXO6 (FBXO6 Produits)
- Synonymes
- anticorps FBG2, anticorps FBS2, anticorps FBX6, anticorps Fbx6b, anticorps AA408845, anticorps Fbs2, anticorps Fbxo6b, anticorps Fbg2, anticorps FBXO6, anticorps fbg2, anticorps fbs2, anticorps fbx6, anticorps fbx6b, anticorps fbxo44, anticorps F-box protein 6, anticorps F-box protein 6 S homeolog, anticorps FBXO6, anticorps Fbxo6, anticorps fbxo6.S
- Sujet
- Synonyms:FBG2, FBS2, FBX6 Background:Substrate-recognition component of some SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway(ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1(phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
- Poids moléculaire
- 35 kDa
- ID gène
- 26270
- UniProt
- Q9NRD1
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