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FIP1L1 anticorps

FIP1L1 Reactivité: Humain, Souris, Rat WB, IHC, IF, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5702829
  • Antigène Voir toutes FIP1L1 Anticorps
    FIP1L1 (FIP1 Like 1 (FIP1L1))
    Reactivité
    • 26
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 24
    • 2
    Lapin
    Clonalité
    • 24
    • 2
    Polyclonal
    Conjugué
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FIP1L1 est non-conjugé
    Application
    • 26
    • 13
    • 13
    • 7
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA
    Immunogène
    FIP1 like 1 (S. cerevisiae)
    Isotype
    IgG
    Top Product
    Discover our top product FIP1L1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    K-562 cells were subjected to SDS PAGE followed by western blot with FNab03131(FIP1L1 antibody) at dilution of 1:300

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze / thaw cycles.
    Stock
    -20 °C
    Date de péremption
    12 months
  • Antigène
    FIP1L1 (FIP1 Like 1 (FIP1L1))
    Autre désignation
    FIP1L1 (FIP1L1 Produits)
    Synonymes
    anticorps FIP1, anticorps Rhe, anticorps hFip1, anticorps 1300019H17Rik, anticorps Rje, anticorps fip1l1, anticorps wu:fd36f11, anticorps zgc:103421, anticorps factor interacting with PAPOLA and CPSF1, anticorps factor interacting with PAPOLA and CPSF1 S homeolog, anticorps FIP1 like 1 (S. cerevisiae), anticorps FIP1 like 1b (S. cerevisiae), anticorps fip1l1, anticorps FIP1L1, anticorps fip1l1.S, anticorps Fip1l1, anticorps fip1l1b
    Sujet
    Synonyms:FIP1, RHE Background:This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
    Poids moléculaire
    67 kDa
    ID gène
    81608
    UniProt
    Q6UN15
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