GEMIN5 anticorps
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- Antigène Voir toutes GEMIN5 Anticorps
- GEMIN5 (Gem (Nuclear Organelle) Associated Protein 5 (GEMIN5))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GEMIN5 est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Immunogène
- gem (nuclear organelle) associated protein 5
- Isotype
- IgG
- Top Product
- Discover our top product GEMIN5 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03420( GEMIN5 Antibody) at dilution of 1:1500
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- GEMIN5 (Gem (Nuclear Organelle) Associated Protein 5 (GEMIN5))
- Autre désignation
- GEMIN5 (GEMIN5 Produits)
- Synonymes
- anticorps GEMIN-5, anticorps AA407055, anticorps AA407208, anticorps AI451603, anticorps BB194447, anticorps C330013N08, anticorps gem nuclear organelle associated protein 5, anticorps gem (nuclear organelle) associated protein 5, anticorps GEMIN5, anticorps Gemin5
- Sujet
- Synonyms: Background:The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins(snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex.
- Poids moléculaire
- 168 kDa
- ID gène
- 25929
- UniProt
- Q8TEQ6
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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