PAF1/PD2 anticorps

N° du produit ABIN5704209

Détail du produit anti-PAF1/PD2 anticorps

Antigène: PAF1/PD2 (PAF1) (Paf1, RNA Polymerase II Associated Factor, Homolog (PAF1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAF1/PD2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Immunogène: Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06106(PAF1 antibody) at dilution of 1:1000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur PAF1/PD2

Antigène: PAF1/PD2 (PAF1) (Paf1, RNA Polymerase II Associated Factor, Homolog (PAF1))

Autre désignation: PAF1 (PAF1 Produits)

Synonymes: anticorps F23149_1, anticorps PD2, anticorps 5730511K23Rik, anticorps AA675045, anticorps f23149_1, anticorps pd2, anticorps im:6906070, anticorps paf1l, anticorps wu:fb80a09, anticorps paf1, anticorps RGD1306219, anticorps PAF1 homolog, Paf1/RNA polymerase II complex component, anticorps Paf1, RNA polymerase II complex component, anticorps PAF1 homolog, Paf1/RNA polymerase II complex component L homeolog, anticorps RNA polymerase II-associated factor 1 homolog pseudogene, anticorps RNA polymerase II-associated factor 1 homolog, anticorps paf1, RNA polymerase II associated factor, homolog (S. cerevisiae), anticorps Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae), anticorps PAF1, anticorps Paf1, anticorps paf1, anticorps paf1.L, anticorps LOC100019208, anticorps LOC100161171, anticorps LOC100639019, anticorps LOC100650306

Sujet: Synonyms:PD2 Background:Component of the PAF1 complex(PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'-and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4'(H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B(H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro.

ID gène: 54623

UniProt: Q8N7H5

Pathways: Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance