SIX2 anticorps

N° du produit ABIN5704361

Détail du produit anti-SIX2 anticorps

Antigène: SIX2 (SIX Homeobox 2 (SIX2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIX2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Immunogène: SIX homeobox 2

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab07887( SIX2 Antibody) at dilution of 1:600

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur SIX2

Antigène: SIX2 (SIX Homeobox 2 (SIX2))

Autre désignation: SIX2 (SIX2 Produits)

Synonymes: anticorps six2-A, anticorps zgc:195089, anticorps zgc:195096, anticorps six2.1, anticorps wu:fj04e08, anticorps zgc:91945, anticorps SIX homeobox 2, anticorps sine oculis-related homeobox 2, anticorps SIX homeobox 2 S homeolog, anticorps SIX homeobox 2b, anticorps SIX homeobox 2a, anticorps SIX2, anticorps Six2, anticorps six2.S, anticorps six2b, anticorps six2a

Sujet: Synonyms:Homeobox protein SIX2, Sine oculis homeobox homolog 2, SIX homeobox 2, SIX2 Background:Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development(By similarity). Plays a role in cell proliferation and migration.

ID gène: 10736

UniProt: Q9NPC8

Pathways: Protein targeting to Nucleus