MUC16 anticorps

N° du produit ABIN5707666

Détail du produit anti-MUC16 anticorps

Antigène: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MUC16 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Purified

Pureté: Protein A affinity chromatography

Immunogène: A recombinant partial protein was used as the immunogen for the recombinant MUC16 antibody.

Clone: OCA125-2349R

Isotype: IgG kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant MUC16 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant MUC16 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur MUC16

Antigène: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Autre désignation: MUC16 / CA125 (CA125 Produits)

Synonymes: anticorps CA125, anticorps 1110008I14Rik, anticorps Ca125, anticorps Gm1480, anticorps RGD1308422, anticorps MUC16, anticorps mucin 16, cell surface associated, anticorps mucin 16, anticorps mucin-16, anticorps MUC16, anticorps Muc16, anticorps LOC476718, anticorps LOC712735

Sujet: The mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs). Membrane-associated and secretory mucins are high molecular weight glycoproteins of the glycocalyx (polysaccharide biofilm) that protects mucosal epithelium from particulate matter and microorganisms. Epithelial mucins are large, secreted and cell surface glycoproteins crucial for adhesion modulation, signaling and epithelial cell protection. The number of repeats is highly polymorphic and varies among different alleles. The Mucin family consists of Mucins 1-4, Mucin 5 (AC and B), 6-8, 11-13 and 15-17. The Mucin 16 protein (also commonly referred to as CA125), encoded for by the gene MUC16, is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain, an extracellular domain and an amino terminal domain. Mucin 16, an ovarian cancer-associated antigen, is used as a marker to monitor the progress of epithelial ovarian cancer. It is a hydrophilic membrane-associated protein that may be involved in vitamin A functions.