MAML2 anticorps

N° du produit ABIN5707977

Détail du produit anti-MAML2 anticorps

Antigène: MAML2 (Mastermind-Like 2 (MAML2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAML2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Purified

Pureté: Protein G affinity chromatography

Immunogène: A human recombinant full length protein was used as the immunogen for this MAML2 antibody.

Clone: MAML2-1302

Isotype: IgG2a

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MAML2 antibody to be titered up or down for optimal performance.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Western blot: 0.5-1 μg/mL,FACS: 0.5-1 μg/10^6 cells,Immunofluorescence: 1-2 μg/mL,Immunohistochemistry (FFPE): 0.5-1 μg/mL,Prediluted IHC only format : incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the MAML2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur MAML2

Antigène: MAML2 (Mastermind-Like 2 (MAML2))

Autre désignation: MAML2 (MAML2 Produits)

Synonymes: anticorps 5930431H10, anticorps BC032967, anticorps MAM-3, anticorps MAM2, anticorps MAM3, anticorps MLL-MAML2, anticorps mastermind like 2 (Drosophila), anticorps mastermind-like transcriptional coactivator 2, anticorps mastermind like transcriptional coactivator 2, anticorps Maml2, anticorps MAML2

Sujet: Mastermind-like 2, also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, it interacts with the ankyrin repeats of the Notch proteins (1-4). This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.