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MAML3 anticorps

MAML3 Reactivité: Humain FACS, IF, IHC (p) Hôte: Souris Monoclonal MAML3-1303 unconjugated
N° du produit ABIN5707997
  • Antigène Voir toutes MAML3 Anticorps
    MAML3 (Mastermind-Like 3 (MAML3))
    Reactivité
    • 42
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 29
    • 13
    Souris
    Clonalité
    • 30
    • 12
    Monoclonal
    Conjugué
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MAML3 est non-conjugé
    Application
    • 15
    • 13
    • 13
    • 12
    • 11
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Purified
    Pureté
    Protein G affinity chromatography
    Immunogène
    A human full length recombinant protein was used as the immunogen for this MAML3 antibody.
    Clone
    MAML3-1303
    Isotype
    IgG1
    Top Product
    Discover our top product MAML3 Anticorps primaire
  • Indications d'application
    The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MAML3 antibody to be titered up or down for optimal performance.\. FACS: 0.5-1 μg/10^6 cells,Immunofluorescence: 1-2 μg/mL,Immunohistochemistry (FFPE): 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    1 mg/mL in 1X PBS, BSA free, sodium azide free
    Agent conservateur
    Azide free
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store the MAML3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • Antigène
    MAML3 (Mastermind-Like 3 (MAML3))
    Autre désignation
    MAML3 (MAML3 Produits)
    Synonymes
    anticorps AV234550, anticorps BC049812, anticorps Mam-2, anticorps mKIAA1816, anticorps Glrp1, anticorps CAGH3, anticorps ERDA3, anticorps GDN, anticorps MAM-2, anticorps MAM2, anticorps TNRC3, anticorps mastermind like 3 (Drosophila), anticorps mastermind-like transcriptional coactivator 3, anticorps mastermind like transcriptional coactivator 3, anticorps Maml3, anticorps MAML3
    Sujet
    Mastermind-like 3 is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch 1-4 proteins. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, its upregulation is thought to be involved in oncogenesis.
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