NUDT1 anticorps
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- Antigène Voir toutes NUDT1 Anticorps
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NUDT1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- This antibody ist KO validated.
- Purification
- Affinity purification
- Classe de qualité
- KO Validated
- Immunogène
- Recombinant fusion protein of human NUDT1 (NP_945192.1).
- Isotype
- IgG
- Top Product
- Discover our top product NUDT1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000 IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
- Autre désignation
- NUDT1 (NUDT1 Produits)
- Synonymes
- anticorps mutT, anticorps nudT1, anticorps MTH1, anticorps Mth1, anticorps 7,8-dihydro-8-oxoguanine triphosphatase, anticorps nudix hydrolase 1, anticorps nudix (nucleoside diphosphate linked moiety X)-type motif 1, anticorps mth1, anticorps Tsp_07498, anticorps nudt1, anticorps 8odp, anticorps NUDT1, anticorps Nudt1
- Sujet
- Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
- Poids moléculaire
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Observed_MW: Refer to Figures
Calculated_MW: 17kDa/19kDa/20kDa/22kDa
- ID gène
- 4521
- UniProt
- P36639
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