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NUDT1 anticorps

KO Validated NUDT1 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5966340
  • Antigène Voir toutes NUDT1 Anticorps
    NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
    Reactivité
    • 30
    • 13
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 27
    • 3
    Lapin
    Clonalité
    • 26
    • 4
    Polyclonal
    Conjugué
    • 19
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NUDT1 est non-conjugé
    Application
    • 18
    • 8
    • 6
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    This antibody ist KO validated.
    Purification
    Affinity purification
    Classe de qualité
    KO Validated
    Immunogène
    Recombinant fusion protein of human NUDT1 (NP_945192.1).
    Isotype
    IgG
    Top Product
    Discover our top product NUDT1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000 IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
    Autre désignation
    NUDT1 (NUDT1 Produits)
    Synonymes
    anticorps mutT, anticorps nudT1, anticorps MTH1, anticorps Mth1, anticorps 7,8-dihydro-8-oxoguanine triphosphatase, anticorps nudix hydrolase 1, anticorps nudix (nucleoside diphosphate linked moiety X)-type motif 1, anticorps mth1, anticorps Tsp_07498, anticorps nudt1, anticorps 8odp, anticorps NUDT1, anticorps Nudt1
    Sujet
    Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
    Poids moléculaire

    Observed_MW: Refer to Figures

    Calculated_MW: 17kDa/19kDa/20kDa/22kDa

    ID gène
    4521
    UniProt
    P36639
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