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CCAR2 anticorps

CCAR2 Reactivité: Humain, Souris, Rat IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5968415
  • Antigène Voir toutes CCAR2 Anticorps
    CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))
    Reactivité
    • 29
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 19
    • 8
    • 2
    Lapin
    Clonalité
    • 22
    • 7
    Polyclonal
    Conjugué
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CCAR2 est non-conjugé
    Application
    • 20
    • 11
    • 11
    • 6
    • 4
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein of human CCAR2 (NP_066997.3).
    Isotype
    IgG
    Top Product
    Discover our top product CCAR2 Anticorps primaire
  • Indications d'application
    IHC 1:50-1:200 IF 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))
    Autre désignation
    CCAR2 (CCAR2 Produits)
    Synonymes
    anticorps DBC-1, anticorps DBC1, anticorps KIAA1967, anticorps NET35, anticorps p30 DBC, anticorps p30DBC, anticorps 2610301G19Rik, anticorps mKIAA1967, anticorps RGD1309922, anticorps Kiaa1967, anticorps cell cycle and apoptosis regulator 2, anticorps cell cycle activator and apoptosis regulator 2, anticorps CCAR2, anticorps Ccar2
    Sujet
    Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation, stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978).
    Poids moléculaire

    Observed_MW: 100kDa

    Calculated_MW: 102kDa/103kDa

    ID gène
    57805
    UniProt
    Q8N163
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