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AF4 anticorps (AA 1124-1218)

AFF1 Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6136612
  • Antigène Tous les produits AF4 (AFF1)
    AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
    Épitope
    • 15
    • 8
    • 8
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    AA 1124-1218
    Reactivité
    • 44
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 42
    • 2
    Lapin
    Clonalité
    • 42
    • 2
    Polyclonal
    Conjugué
    • 20
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp AF4 est non-conjugé
    Application
    • 23
    • 19
    • 13
    • 13
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Séquence
    SQSSAGSVGS SGVAATISTP VTIQNMTSSY VTITSHVLTA FDLWEQAEAL TRKNKEFFAR LSTNVCTLAL NSSLVDLVHY TRQGFQQLQE LTKTP
     Réactivité croisée
    Humain, Rat
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 1124-1218 of human AFF1 (NP_001160165.1).
    Isotype
    IgG
  • Indications d'application
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
    Autre désignation
    AFF1 (AFF1 Produits)
    Synonymes
    anticorps AF4, anticorps MLLT2, anticorps PBM1, anticorps 9630032B01Rik, anticorps AW319193, anticorps Af4, anticorps Mllt2h, anticorps Rob, anticorps Mllt2, anticorps AF4/FMR2 family member 1, anticorps AF4/FMR2 family, member 1, anticorps AFF1, anticorps Aff1
    Sujet
    This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.,AFF1,AF4,MLLT2,PBM1,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,AFF1
    Poids moléculaire
    131 kDa/132 kDa
    ID gène
    4299
    UniProt
    P51825
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