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DDIT4 anticorps (AA 1-232)

DDIT4 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6139465
  • Antigène Voir toutes DDIT4 Anticorps
    DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
    Épitope
    • 15
    • 14
    • 13
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-232
    Reactivité
    • 54
    • 23
    • 9
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 65
    • 4
    Lapin
    Clonalité
    • 67
    • 2
    Polyclonal
    Conjugué
    • 28
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DDIT4 est non-conjugé
    Application
    • 46
    • 33
    • 26
    • 13
    • 13
    • 13
    • 8
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB)
    Séquence
    MPSLWDRFSS SSTSSSPSSL PRTPTPDRPP RSAWGSATRE EGFDRSTSLE SSDCESLDSS NSGFGPEEDT AYLDGVSLPD FELLSDPEDE HLCANLMQLL QESLAQARLG SRRPARLLMP SQLVSQVGKE LLRLAYSEPC GLRGALLDVC VEQGKSCHSV GQLALDPSLV PTFQLTLVLR LDSRLWPKIQ GLFSSANSPF LPGFSQSLTL STGFRVIKKK LYSSEQLLIE EC
     Réactivité croisée
    Humain, Souris
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-232 of human DDIT4 (NP_061931.1).
    Isotype
    IgG
    Top Product
    Discover our top product DDIT4 Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
    Autre désignation
    DDIT4 (DDIT4 Produits)
    Synonymes
    anticorps redd1, anticorps Dig2, anticorps REDD-1, anticorps REDD1, anticorps 5830413E08Rik, anticorps AA415483, anticorps Rtp801, anticorps dig2, anticorps rtp801, anticorps sb:cb821, anticorps zgc:64114, anticorps DNA damage inducible transcript 4, anticorps DNA-damage-inducible transcript 4, anticorps DNA damage inducible transcript 4 S homeolog, anticorps ddit4, anticorps DDIT4, anticorps Ddit4, anticorps ddit4.S
    Sujet
    Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1. Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type, it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity. Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.,DDIT4,Dig2,REDD-1,REDD1,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,mTOR Signaling Pathway,Endocrine & Metabolism,Neuroscience,Neurodegenerative Diseases,Dopamine Signaling in Parkinson's Disease,Neurodegenerative Diseases Markers,Cardiovascular,Hypoxia,Hypoxia-Regulated,DDIT4
    Poids moléculaire
    25 kDa
    ID gène
    54541
    UniProt
    Q9NX09
    Pathways
    Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process
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