DIO3 anticorps (AA 70-170)

N° du produit ABIN6139627

Détail du produit anti-DIO3 anticorps

Antigène: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Épitope: AA 70-170

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIO3 est non-conjugé

Application: Western Blotting (WB)

Séquence: HFLGRRRRGQ PEPEVELNSE GEEVPPDDPP ICVSDDNRLC TLASLKAVWH GQKLDFFKQA HEGGPAPNSE VVLPDGFQSQ HILDYAQGNR PLVLNFGSCT U

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 70-170 of human DIO3 (NP_001353.4).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur DIO3

Antigène: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Autre désignation: DIO3 (DIO3 Produits)

Synonymes: anticorps 5DIII, anticorps DIOIII, anticorps txdi3, anticorps dioiii, anticorps XL-15, anticorps itdi3, anticorps D3, anticorps TXDI3, anticorps iodothyronine deiodinase 3, anticorps deiodinase, iodothyronine, type 3, anticorps deiodinase, iodothyronine, type III, anticorps deiodinase, iodothyronine type III, anticorps deiodinase, iodothyronine, type 3 L homeolog, anticorps DIO3, anticorps dio3, anticorps Dio3, anticorps dio3.L

Sujet: The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.,DIO3,5DIII,D3,DIOIII,TXDI3,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Neuroscience,DIO3

Poids moléculaire: 33 kDa

ID gène: 1735

UniProt: P55073

Pathways: Hormone Activity