FIP1L1 anticorps (AA 1-300)

N° du produit ABIN6140640

Détail du produit anti-FIP1L1 anticorps

Antigène: FIP1L1 (FIP1 Like 1 (FIP1L1))

Épitope: AA 1-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FIP1L1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Séquence: MSAGEVERLV SELSGGTGGD EEEEWLYGDE NEVERPEEEN ASANPPSGIE DETAENGVPK PKVTETEDDS DSDSDDDEDD VHVTIGDIKT GAPQYGSYGT APVNLNIKTG GRVYGTTGTK VKGVDLDAPG SINGVPLLEV DLDSFEDKPW RKPGADLSDY FNYGFNEDTW KAYCEKQKRI RMGLEVIPVT STTNKITAED CTMEVTPGAE IQDGRFNLFK VQQGRTGNSE KETALPSTKA EFTSPPSLFK TGLPPSRNST SSQSQTSTAS RKANSSVGKW QDRYGRAESP DLRRLPGAID

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FIP1L1 (NP_001128409.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur FIP1L1

Antigène: FIP1L1 (FIP1 Like 1 (FIP1L1))

Autre désignation: FIP1L1 (FIP1L1 Produits)

Synonymes: anticorps FIP1, anticorps Rhe, anticorps hFip1, anticorps 1300019H17Rik, anticorps Rje, anticorps fip1l1, anticorps wu:fd36f11, anticorps zgc:103421, anticorps factor interacting with PAPOLA and CPSF1, anticorps factor interacting with PAPOLA and CPSF1 S homeolog, anticorps FIP1 like 1 (S. cerevisiae), anticorps FIP1 like 1b (S. cerevisiae), anticorps fip1l1, anticorps FIP1L1, anticorps fip1l1.S, anticorps Fip1l1, anticorps fip1l1b

Sujet: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,FIP1L1,FIP1,Rhe,hFip1,Epigenetics & Nuclear Signaling,RNA Binding,FIP1L1

Poids moléculaire: 40 kDa/58 kDa/65 kDa/66 kDa

ID gène: 81608

UniProt: Q6UN15