GIPR anticorps (AA 22-138)

N° du produit ABIN6141096

Détail du produit anti-GIPR anticorps

Antigène: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Épitope: AA 22-138

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GIPR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: RAETGSKGQT AGELYQRWER YRRECQETLA AAEPPSGLAC NGSFDMYVCW DYAAPNATAR ASCPWYLPWH HHVAAGFVLR QCGSDGQWGL WRDHTQCENP EKNEAFLDQR LILERLQ

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 22-138 of human GIPR (NP_000155.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-GIPR (ABIN6141096)

Ussher, Campbell, Mulvihill, Baggio, Bates, McLean, Gopal, Capozzi, Yusta, Cao, Ali, Kim, Kabir, Seino, Suzuki, Drucker: "Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction." dans: Cell metabolism, Vol. 27, Issue 2, pp. 450-460.e6, (2018) (PubMed).

Détails sur GIPR

Antigène: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Autre désignation: GIPR (GIPR Produits)

Synonymes: anticorps GIPR, anticorps PGQTL2, anticorps GIP-R, anticorps Gm1081, anticorps Gm160, anticorps Gippr, anticorps RATGIPPR, anticorps gastric inhibitory polypeptide receptor, anticorps glucagon receptor, anticorps GIPR, anticorps LOC100303705, anticorps Gipr

Sujet: This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.,GIPR,PGQTL2,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Neuroscience,GIPR

Poids moléculaire: 48 kDa/49 kDa/53 kDa

ID gène: 2696

UniProt: P48546

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling