LAMTOR1 anticorps (AA 1-161)

N° du produit ABIN6143083

Détail du produit anti-LAMTOR1 anticorps

Antigène: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Épitope: AA 1-161

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAMTOR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Séquence: MGCCYSSENE DSDQDREERK LLLDPSSPPT KALNGAEPNY HSLPSARTDE QALLSSILAK TASNIIDVSA ADSQGMEQHE YMDRARQYST RLAVLSSSLT HWKKLPPLPS LTSQPHQVLA SEPIPFSDLQ QVSRIAAYAY SALSQIRVDA KEELVVQFGI P

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human LAMTOR1 (NP_060377.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:1000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur LAMTOR1

Antigène: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Autre désignation: LAMTOR1 (LAMTOR1 Produits)

Synonymes: anticorps C11orf59, anticorps PDRO, anticorps Ragulator1, anticorps p18, anticorps p27RF-Rho, anticorps 2400001E08Rik, anticorps Pdro, anticorps C15H11orf59, anticorps c11orf59, anticorps flj20625, anticorps p27rf-rho, anticorps pdro, anticorps ragulator1, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 1, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 S homeolog, anticorps LAMTOR1, anticorps Lamtor1, anticorps lamtor1.S

Sujet: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.,LAMTOR1,C11orf59,PDRO,Ragulator1,p18,p27RF-Rho,Signal Transduction,Kinase,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cardiovascular,Lipids,Regulator of mTOR complex function,Regulators,LAMTOR1

Poids moléculaire: 17 kDa

ID gène: 55004

UniProt: Q6IAA8