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PDHX anticorps (AA 1-300)

PDHX Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6145384
  • Antigène Voir toutes PDHX Anticorps
    PDHX (Pyruvate Dehydrogenase Complex, Component X (PDHX))
    Épitope
    • 15
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-300
    Reactivité
    • 22
    • 20
    • 17
    Humain
    Hôte
    • 34
    • 3
    • 1
    • 1
    Lapin
    Clonalité
    • 38
    • 1
    Polyclonal
    Conjugué
    • 18
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PDHX est non-conjugé
    Application
    • 30
    • 13
    • 13
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Séquence
    MAASWRLGCD PRLLRYLVGF PGRRSVGLVK GALGWSVSRG ANWRWFHSTQ WLRGDPIKIL MPSLSPTMEE GNIVKWLKKE GEAVSAGDAL CEIETDKAVV TLDASDDGIL AKIVVEEGSK NIRLGSLIGL IVEEGEDWKH VEIPKDVGPP PPVSKPSEPR PSPEPQISIP VKKEHIPGTL RFRLSPAARN ILEKHSLDAS QGTATGPRGI FTKEDALKLV QLKQTGKITE SRPTPAPTAT PTAPSPLQAT AGPSYPRPVI PPVSTPGQPN AVGTFTEIPA SNIRRVIAKR LTESKSTVPH
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PDHX (NP_003468.2).
    Isotype
    IgG
    Top Product
    Discover our top product PDHX Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000,IP,1:50 - 1:200
    Commentaires

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    PDHX (Pyruvate Dehydrogenase Complex, Component X (PDHX))
    Autre désignation
    PDHX (PDHX Produits)
    Synonymes
    anticorps DLDBP, anticorps E3BP, anticorps OPDX, anticorps PDX1, anticorps proX, anticorps AI481367, anticorps E3bp, anticorps Pdx1, anticorps Ac1164, anticorps zgc:66110, anticorps zgc:85977, anticorps MGC86218, anticorps PDHX, anticorps DDBDRAFT_0168431, anticorps DDBDRAFT_0230192, anticorps DDB_0168431, anticorps DDB_0230192, anticorps pyruvate dehydrogenase complex component X, anticorps pyruvate dehydrogenase complex, component X, anticorps pyruvate dehydrogenase complex component X L homeolog, anticorps E3-binding protein, anticorps PDHX, anticorps Pdhx, anticorps pdhx, anticorps pdhx.L, anticorps pdhX
    Sujet
    The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit, also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,PDHX,DLDBP,E3BP,OPDX,PDX1,proX,Cancer,Signal Transduction,Endocrine & Metabolism,Carbohydrate metabolism,Warburg Effect,PDHX
    Poids moléculaire
    29 kDa/51 kDa/54 kDa
    ID gène
    8050
    UniProt
    O00330
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