Pellino 1 anticorps (AA 1-250)

N° du produit ABIN6145436

Détail du produit anti-Pellino 1 anticorps

Antigène: Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))

Épitope: AA 1-250

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Pellino 1 est non-conjugé

Application: Western Blotting (WB)

Séquence: MFSPDQENHP SKAPVKYGEL IVLGYNGSLP NGDRGRRKSR FALFKRPKAN GVKPSTVHIA CTPQAAKAIS NKDQHSISYT LSRAQTVVVE YTHDSNTDMF QIGRSTESPI DFVVTDTVPG SQSNSDTQSV QSTISRFACR IICERNPPFT ARIYAAGFDS SKNIFLGEKA AKWKTSDGQM DGLTTNGVLV MHPRNGFTED SKPGIWREIS VCGNVFSLRE TRSAQQRGKM VEIETNQLQD GSLIDLCGAT

Réactivité croisée: Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PELI1 (NP_065702.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Pellino 1

Antigène: Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))

Autre désignation: PELI1 (PELI1 Produits)

Synonymes: anticorps 2810468L03Rik, anticorps A930031K15Rik, anticorps AA409794, anticorps AI586297, anticorps D11Ertd676e, anticorps peli1, anticorps peli1.L, anticorps pellino1, anticorps xpellino1, anticorps wu:fd12d01, anticorps zgc:153297, anticorps pellino E3 ubiquitin protein ligase 1, anticorps pellino 1, anticorps pellino E3 ubiquitin protein ligase 1 S homeolog, anticorps pellino E3 ubiquitin protein ligase 1b, anticorps PELI1, anticorps Peli1, anticorps peli1.S, anticorps peli1b

Sujet: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation, preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3. Negatively regulates necroptosis by reducing RIPK3 expression. Mediates 'Lys-63'-linked ubiquitination of RIPK1.,PELI1,Signal Transduction,Kinase,Immunology & Inflammation,NF-kB Signaling Pathway,PELI1

Poids moléculaire: 46 kDa

ID gène: 57162

UniProt: Q96FA3

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades