ROBO4 anticorps (AA 848-1007)

N° du produit ABIN6147063

Détail du produit anti-ROBO4 anticorps

Antigène: ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (ROBO4))

Épitope: AA 848-1007

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROBO4 est non-conjugé

Application: Western Blotting (WB)

Séquence: GVGPKGGVLL CPPRPCLTPT PSEGSLANGW GSASEDNAAS ARASLVSSSD GSFLADAHFA RALAVAVDSF GFGLEPREAD CVFIDASSPP SPRDEIFLTP NLSLPLWEWR PDWLEDMEVS HTQRLGRGMP PWPPDSQISS QRSQLHCRMP KAGASPVDYS

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 848-1007 of human ROBO4 (NP_061928.4).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ROBO4

Antigène: ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (ROBO4))

Autre désignation: ROBO4 (ROBO4 Produits)

Synonymes: anticorps ECSM4, anticorps MRB, anticorps 1200012D01Rik, anticorps AI593217, anticorps sc:d0823, anticorps wu:fa16f09, anticorps roundabout guidance receptor 4, anticorps roundabout, axon guidance receptor, homolog 4 (Drosophila), anticorps ROBO4, anticorps Robo4, anticorps robo4

Sujet: Roundabout homolog 4, also known as magic roundabout and ROBO4 is a member of the immunoglobulin superfamily and ROBO family. ROBO4 is specifically expressed in endothelial cells. It is expressed at sites of angiogenesis in different tumor types. ROBO4 contains two fibronectin type-III domains and two Ig-like C2-type (immunoglobulin-like) domains. ROBO4 is the fourth identified member of the roundabout receptor family. It is the only Robo family member expressed in primary endothelial cells and that application of Slit inhibits their migration. ROBO4 is predominantly expressed in embryonic or tumor vascular endothelium and is considered important for vascular development and as a candidate tumor endothelial marker. ROBO4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development. ROBO4 is a receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO4 may mediate the inhibition of primary endothelial cell migration by Slit proteins. Activating ROBO4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak.,ROBO4,ECSM4,MRB,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Extracellular Matrix,Neuroscience,Cardiovascular,Angiogenesis,ROBO4

Poids moléculaire: 75 kDa/98 kDa/107 kDa

ID gène: 54538

UniProt: Q8WZ75